I was just prescribed Indomethacin a few of weeks ago. Saw a new Dr. and he instructed me to stop taking Motrin, which I was trying to wean myself off of, and take Indomethacin 3x a day at 25mg. The first week transition was tough, but now I am very happy with how it works, much better then what I was taking and have found that most days I only take 2x a day. I did wake up one night with a headache and took one, and was pleased to see how fast it took effect. I know the Dr. wants to completely get me off of this med as he is slowly ramping me up on another, but for this right now, I have been pleased as I feel I am functioning in daily life much better. He did also prescribe something to take to protect my stomach, which I have been taking. Good luck!