Many people ask for links about NF2. It is not easy for me to paste links. I hope his can be useful
Diagnostic Criteria for NF-1
Two or more of the following: *
1. Six or more café-au-lait spots 1.5 cm or larger in post-pubertal individuals, 0.5 cm or larger in pre-pubertal individuals
2. Two or more neurofibromas of any type or one or more plexiform neurofibroma
3. Freckling in the axilla or groin
4. Optic glioma (tumor of the optic pathway)
5. Two or more Lisch nodules (benign iris hamartomas)
6. A distinctive bony lesion: dysplasia of the sphenoid bone or dysplasia or thinning of long bone cortex
7. A first-degree relative with NF1
Presumptive (probable) NF2:
1. Bilateral vestibular schwannomas (VS) (also known as acoustic neuroma)
2. Family history of NF2 (first degree family relative) plus:
3. Unilateral VS or any two of the following:
meningioma, glioma, schwannoma, juvenile posterior subcapsular lenticular opacity, juvenile cortical cataract
Individuals with the following clinical features should be evaluated for NF2:
Diagnostic Criteria for NF-2
1. Unilateral VS plus at least two of any of the following: meningioma, glioma, schwannoma, juvenile posterior subcapsular lenticular opacities/juvenile cortical cataract
2. Multiple meningiomas (2 or more) plus unilateral VS or any two of the following: glioma, schwannoma, juvenile posterior subcapsular lenticular opacities/juvenile cortical cataract
Effects of NF2
Neurofibromatosis type 2 (NF-2) is an autosomal dominant genetic disorder that causes tumors to form on the nerves of the central nervous system, in the brain, and on the spine. It affects one in 33,000-40,000 males and females of all races and ethnic groups. The NF-2 gene is located on chromosome 22.
NF-Related Articles, Abstracts, and Research Highlights[/u]
* E-Medicine: Dermatologic Manifestations of Neurologic Disease
Theresa Conologue, DO, Staff Physician, Department of Dermatology, National Capital Consortium/Walter Reed Army Medical Center
*
Medical Journal Abstracts (Pub Med)
Enter search criteria (e.g. 'NF1' or 'neurofibromatosis') in the space provided.
Click "Go."
*
NF-1
Do hormonal contraceptives stimulate growth of neurofibromas? A survey on 59
NF1 patients
Marge Lammert, Victor-Felix Mautner, and Lan Kluwe
Superficial Neurofibroma: A Lesion with Unique MRI Characteristics in
Patients with Neurofibromatosis Type 1
Ruth Lim, Diego Jaramillo, Tina Young Poussaint, Yuchiao Chang and
Bruce Korf
NF: Brain tumor study reveals why treatment efforts fail in genetic disorder
From Washington University School of Medicine
Neurofibromatous neuropathy in neurofibromatosis 1 (NF1).
Ferner RE, Hughes RA, Hall SM, Upadhyaya M, Johnson MR.
* NF-2
Incidence of vestibular schwannoma and neurofibromatosis 2 in the North West
of England over a 10-year period: higher incidence than previously thought.
(Abstract)
Evans DG, Moran A, King A, Saeed S, Gurusinghe N, Ramsden R.
Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to
Grb2 protein. (Abstract)
Lim JY, Kim H, Jeun SS, Kang SG, Lee KJ.
Methodological issues in longitudinal studies: vestibular schwannoma
growth rates in NF2. (Abstract)
Baser, Me, Mautner VF, Parry DM, Evans G.
Neurotologic skull base surgery in pediatric patients. (Abstract)
Cunningham CD 3rd, Friedman RA, Brackmann DE, Hitselberger WE, Lin HW.
Simultaneous cochlear implantation and translabyrinthine removal of vestibular schwannoma in only hearing ear. (Abstract)
Aristegui M, Denia A.
Treatment of schwannomas with an oncolytic recombinant herpes simplex virus
in murine models of neurofibromatosis type 2. (Abstract)
Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R,
Martuza R, Rabkin S, Breakefield XO
