Author Topic: Stress and AN  (Read 408 times)

mwatto

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Stress and AN
« on: September 25, 2022, 03:05:08 am »
Read this today: Stress has been postulated to trigger or contribute to inner ear pathologies but there is little objective evidence. We investigated stress hormones in Ménière's patients and patients with acoustic neuroma. Data were compared with those from a control group of patients with facial spasm. We assayed classic stress hormones including adrenocorticotropic hormone, cortisol, growth hormone and prolactin. We found a strong positive correlation between cortisol and adrenocorticotropic hormone in Ménière patients and patients with acoustic neuroma but no correlation in patients with facial spasm. The data also revealed in female patients with Ménière's disease or with acoustic neuroma an unexpected significant positive correlation between cortisol and prolactin. The data showed the expected negative correlation or no correlation between cortisol and prolactin associated with males and females in the other patient groups. Both cortisol and prolactin increases are known to represent alternative strategies to cope with stress, and our data point to prolactin being possibly more dominant in Ménière's disease and cortisol in acoustic neuroma. These data provide further evidence for modification of different stress hormones in audiovestibular pathologies, which might provide a valuable diagnostic or prognostic tool in the future.
Michele
20 x19x14mm AN diagnosed Feb 2019. Cyberknife .
Mri Oct 2019 showed shrinking to: 18x17x13 mm.
Mri Oct 2020 - no cystic components visible now. Slight shrinking, stable.
MRI 2021 stable no change
MRI 2022 stable no change.

donjehle

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Re: Stress and AN
« Reply #1 on: September 27, 2022, 08:36:01 pm »
Do you have a reference for that, Michele?  It sounds very interesting!
Burning Tongue, Loss of Hearing & Balance, and Tinnitus led to MRI. Very small AN found on 11/23/2021
While watching and waiting, lost significant hearing. WRS now at 12% (down from 100%). Was fitted with CROS system on 3/7/22.  Stable MRI on 7/29/22
No treatment yet.

mwatto

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Re: Stress and AN
« Reply #2 on: September 27, 2022, 08:58:42 pm »
Hi Donjehle -its not recent but here you go...
https://pubmed.ncbi.nlm.nih.gov/15925138/

and this on inflammation: https://academic.oup.com/neuro-oncology/article/21/3/314/5155625

Michele
20 x19x14mm AN diagnosed Feb 2019. Cyberknife .
Mri Oct 2019 showed shrinking to: 18x17x13 mm.
Mri Oct 2020 - no cystic components visible now. Slight shrinking, stable.
MRI 2021 stable no change
MRI 2022 stable no change.

mwatto

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Re: Stress and AN
« Reply #3 on: September 27, 2022, 09:08:13 pm »
Donjehle the shwannoma cell is a type of glial cell in AN so  I take a glial modulator  PEA (palmidrol) Herbs of Gold otc but any pharmacy will have and its also available compounded. The PEA works on inflammation especially neuro inflammation- calms overactive glial cells that cause nerve pain eg. Its a natural compound been used since the 50s and no side effects or drug interactions. Its a natural analgesic. https://accurateclinic.com/accurate-education-palmitoylethanolamide-pea/
Essentially I try and calm the CNS and view AN as an inflammatory brain disease. Thats my impression anyway. LDN works in a similar way to PEA to calm inflammation.
Michele
20 x19x14mm AN diagnosed Feb 2019. Cyberknife .
Mri Oct 2019 showed shrinking to: 18x17x13 mm.
Mri Oct 2020 - no cystic components visible now. Slight shrinking, stable.
MRI 2021 stable no change
MRI 2022 stable no change.

SP

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Re: Stress and AN
« Reply #4 on: September 28, 2022, 04:58:58 am »
Very interesting article Michele !- thanks for posting. Calming the CNS sounds like a really good idea.
hope you're keeping really well

Stella
2.3 x 2.2 Left AN (June 2022) @7yrs
2.9 x 2.9 (May 2020) @5yrs
2.9 cm (Mar 2019) @4yrs
2.9 cm (Aug 2018) @3yrs
3.1 cm (Aug 2017) @2yrs
3.2 cm (Aug 2016) @1yr
3.2 x 3.0 x 2.5cm Left AN (Aug 2015) ==> CK @ Stanford, August 17-19, 2015 (Drs. Chang & Soltys)

mwatto

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Re: Stress and AN
« Reply #5 on: September 29, 2022, 07:53:48 pm »
Hi Stella yes all is well- I still get some nerve pain at 3 and a half years but I am pleased to say it seems fine mostly now. Maybe my supplements/herbals etc are working. I am on PEA also at the moment after a non covid respiriatory viral infection.
Michele
20 x19x14mm AN diagnosed Feb 2019. Cyberknife .
Mri Oct 2019 showed shrinking to: 18x17x13 mm.
Mri Oct 2020 - no cystic components visible now. Slight shrinking, stable.
MRI 2021 stable no change
MRI 2022 stable no change.

 


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