Author Topic: New compound to treat AN abt to go to trial!  (Read 912 times)

mwatto

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New compound to treat AN abt to go to trial!
« on: November 29, 2022, 08:48:06 pm »
https://scienmag.com/new-experimental-treatment-can-stop-the-growth-of-schwannoma-tumors/

I wrote to them and this response:
Currently we are to the point where the drugs from Vivace are effective both in vitro and in the mouse model. I’m a biologist and not a clinician, so I cannot really comment on their use either pre- or post-radiotherapy. A drug from the same class of compounds is currently in Phase 1 clinical trials for mesothelioma (another NF2-nul tumour).

https://clinicaltrials.gov/ct2/show/NCT04665206

This will report in Feb 2024.

My understanding is that if the Phase 1 trial goes well, they will commence with recruiting for trials for schwannoma.

 
Michele
20 x19x14mm Cystic AN diagnosed Feb 2019. CK.
Mri 2019 shrinking: 18x17x13 mm.
Mri 2020 - no cysts visible stable.
MRI 2021 stable no change
MRI 2022 stable no change.
MRI 2023 Further reduction 12x12x10mm!! Hearing 85%
MRI 2024: No change AN or hearing

donjehle

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Re: New compound to treat AN abt to go to trial!
« Reply #1 on: December 03, 2022, 03:45:12 pm »
Thank you for sharing this, Michele!
Burning Tongue, Loss of Hearing & Balance, and Tinnitus led to MRI. Very small AN found on 11/23/2021
While watching and waiting, lost significant hearing. WRS now at 12% (down from 100%). Was fitted with CROS system on 3/7/22.  Stable MRI on 7/29/22
No treatment yet.