I have been using ointment at bedtime for these past 20 months. Used mostly Refresh PM ointment but it apparently is off the market. Been everywhere. The CVS brand has the same balance of ingredients but I've noticed recently that my eye bothers me at night time so I thought I'd better switch brands. CVS now has Retaine Nighttime, it's preservative free, but I never heard of that brand, in fact neither did the pharmacist. Anyway, I purchased it. And just applied it. So my question is has anyone tried that brand. My dry eye is way better but my doctor recommends continuing with drops daytime and ointment at night. Thanks everyone. Joan